Jacob Murphy and Alexander Isak each scored twice and Joelinton added another as Newcastle scythed through a porous visiting defence that was already under the spotlight from last week’s defeat against Bournemouth.
The embarrassing defeat is a significant blow to Spurs’ dwindling hopes of securing Champions League qualification – but in contrast the Magpies are now in a commanding position to finish in the top four as they climb to third.
Newcastle started with pace and ferocity, taking just 62 seconds to open the scoring.
Joelinton drove inside from the edge of the box and his low shot was parried weakly by Hugo Lloris into the path of Murphy, who was there to smash in the loose ball.
Five minutes later, Brazilian midfielder Joelinton sprung a shambolic Spurs offside trap and rounded Lloris to double the lead.
With the home fans still celebrating, Murphy rattled in the third with a curling shot from distance that Lloris – who was replaced by Fraser Forster at half-time – did not make any attempt to reach.
Sweden striker Isak, averaging a goal every 113 minutes in the Premier League this season prior to the game, then scored twice to compound Spurs’ misery.
First, he met a sumptuous ball from Joe Willock to slot home calmly, then beat the sprawling Lloris from a tight angle.
Kane barged past Fabian Schar and finished neatly to pull one back minutes into the second half but Newcastle responded when Wilson, who had replaced Isak, immediately poked home another from fellow substitute Miguel Almiron’s pass.